By Kunlin Jin, Xunming Ji, Qichuan Zhuge
This booklet covers fresh advances in all points of bone marrow-derived stem cells (BMSCs) for stroke therapy, whereas additionally delivering accomplished info on human medical trials and animal types of stroke. additionally, it experiences the optimum stipulations of transplantation for stroke remedy and strength mechanisms underlying transplanted cell-mediated useful restoration after stroke. because the first publication to target BMSC remedy for stroke, it additionally discusses intensive the original demanding situations of BMSCs-based treatment during this context.
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Extra info for Bone marrow stem cell therapy for stroke
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Ren et al. grate into the parenchymal tissue . In adult mice, gene profile analysis of neural progenitor cells from the SVZ that were isolated by laser-capture microdissection has shown that these cells share more than 70 % of all expressed genes with embryonic cortical neural progenitor cells . In murine neural progenitor cells from the SVZ, stroke activates many genes involved in neurogenesis during embryonic development. The most upregulated genes after stroke are those in the transforming growth factor β superfamily, such as bone morphogenetic protein 8, bone morphogenetic protein type I receptors, and growth differentiation factor 2 .