By Che J. Connon

With contributions from best, overseas teachers and commercial practitioners, Bioprocessing for Cell-Based Therapies explores the very newest recommendations and directions in bioprocess creation to fulfill security, regulatory and moral standards, for the construction of healing cells, together with stem cells.

  • An authoritative, state of the art guide on bioprocessing for the construction of healing cells with large illustrations in complete color throughout
  • An authoritative, state-of-the-art instruction manual on bioprocessing for the construction of healing cells with broad illustrations in complete color throughout
  • In intensity dialogue of the appliance of cellphone treatment together with equipment utilized in the supply of cells to the patient
  • Includes contributions from specialists in either academia and undefined, combining a realistic method with leading edge research
  • The merely instruction manual at the moment on hand to supply a cutting-edge consultant to Bioprocessing protecting the entire diversity of cell-based treatments, from specialists in academia and industry

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Extra resources for Bioprocessing for cell based therapies

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2 Hollow Fibre Reactors Hollow fibre reactors are also used for adherent cell culture. For a given volume of container they maximize the surface area required for cells to adhere and grow whilst also maximizing the nutrient and oxygen exchange to the cells. There are many hollow fibre reactors on the market but all follow the same principles. The nature of hollow fibre bioreactors means that they are continuous, closed systems generally supported by a level of automation that facilitates media flow and mass transfer.

It is the cells themselves, not their products that are the therapy; as is often remarked, in biopharmaceutical manufacture, one throws away the cells, while in cell therapy manufacture, one throws away the medium. A second crucial difference is that biopharmaceutical manufacture relies on a few standard cell types in standard media; cell therapy manufacture is bespoke to each therapy and does not have the benefit of well-developed platform technologies, for the time being at least. One to one cell therapy manufacture uses many of the underlying processes and principles of biopharmaceutical manufacture, but is markedly different in scale and separation technologies.

Hematopoietic stem cell clinical trials and those terminated before completion were excluded. The trials were analyzed using three dimensions, clinician-company, autologous-allogeneic and procedure-product. There have been some substantial changes in the categories of cell therapeutics and in the relative involvement of companies and clinicians in the three years from March 2011. The number of trials using easily administered products has more than doubled; the number of trials involving procedures remains unchanged, thus products are now represented in around 40% of trials, up from around 17% in 2011.

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