By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD

In this up to date variation of Basic Immunology, the authors proceed to convey a transparent, sleek creation to immunology, making this the most obvious selection for modern busy scholars. Their event as academics, direction administrators, and teachers is helping them to distill the center info required to appreciate this advanced box. by utilizing high-quality illustrations, relevant medical situations, and concise, targeted text, it is a completely accessible advent to the workings of the human immune procedure, with an emphasis on scientific relevance.

  • Concise, clinically targeted content is logically organized by way of mechanism for effective mastery of the material.
  • Features an appendix of scientific cases and CD molecules.
  • Includes numerous full-color illustrations, invaluable tables, and chapter outlines.
  • Focus questions within every one bankruptcy are perfect for self-assessment and review.
  • Key points bolded in the course of the textual content make it effortless to find very important information.
  • Presents info in a structure and elegance that maximizes usefulness to scholars and teachers learning medication, allied healthiness fields, and biology.
  • Fully up to date content equips you with the newest suitable advances in immunology.
  • Revised and updated artwork complements your visible studying of significant rules and decreases the over the top actual info present in higher textbooks.
  • Twelve brand-new animations on hand on Student Consult support extra clarify advanced concepts.
  • Student seek advice book model incorporated with buy. This greater booklet event gives you entry to the textual content, figures, photographs, thesaurus of immunology phrases, self-assessment questions, and references on various units.

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Extra info for Basic Immunology: Functions and Disorders of the Immune System, 5e

Example text

The helper T cells then express cytokines and cell surface proteins, which work together to activate the B cells. Some of the progeny of the expanded B cell clones differentiate into antibody-secreting plasma cells. Each B cell secretes antibodies that have the same antigen-binding site as the cell surface antibodies (B cell antigen receptors) that first recognized the antigen. Nonprotein antigens stimulate secretion of antibodies with a limited range of functions and low affinity for the antigen.

We next discuss the properties of these cells and soluble proteins and their roles in innate immune responses. Epithelial Barriers The major interfaces between the body and the external environment—the skin, gastrointestinal tract, respiratory tract, and genitourinary tract—are protected by continuous epithelia that provide physical and chemical barriers against infection (Fig. 2-6). Microbes may enter hosts through these interfaces by physical contact, ingestion, and inhalation. All these portals of entry are lined by continuous epithelia consisting of tightly adherent cells that form a mechanical barrier against microbes.

There are five major families of cellular receptors in innate immunity: TLRs, CLRs (C-type lectin receptors), NLRs (NOD-like receptors), RLRs (RIGlike receptors), and CDSs (cytosolic DNA sensors). Formylpeptide receptors (not shown) are involved in ­migration of leukocytes in response to bacteria. Signals generated by engagement of TLRs activate transcription factors that stimulate expression of genes encoding cytokines, enzymes, and other proteins involved in the antimicrobial functions of activated phagocytes and other cells (Fig.

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