By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD
Understand the entire crucial options in immunology with Basic Immunology: services and problems of the Immune System! This concise, targeted textual content provide you with an up-to-date, available advent to the workings of the human immune approach.
- Efficiently grasp the immunology info you would like through clinically targeted content material, logically prepared through mechanism.
- Apply what you will have discovered to real-world occasions by referencing the appendix of medical circumstances.
- Enhance your learning with the aid of various full-color illustrations and worthy tables, in addition to precis bins, assessment questions, and a word list of immunology terms.
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- Visualize advanced immunology techniques with a totally up to date paintings program.
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Extra resources for Basic Immunology: Functions and Disorders of the Immune System, 4e
By sensing microbes and interacting with lymphocytes, especially T cells, dendritic cells constitute an important bridge between innate and adaptive immunity. We discuss the properties and functions of these cells further in Chapter 3, in the context of antigen display, which is a major function of dendritic cells. Mast Cells Mast cells are bone marrow–derived cells with abundant cytoplasmic granules that are present in the skin and mucosal epithelium. Mast cells can be activated by microbial products binding to TLRs, as part of innate immunity, or by a special antibody-dependent mechanism.
Although our emphasis thus far has been on cellular receptors, the innate immune system also contains several circulating molecules that recognize and provide defense against microbes, as discussed later. COMPONENTS OF INNATE IMMUNITY The components of the innate immune system include epithelial cells, sentinel cells in tissues (macrophages, dendritic cells, and others), NK cells, and a number of plasma proteins. We next discuss the properties of these cells and soluble proteins and their roles in innate immune responses.
2–7, B). They also ingest microbes in the blood and in tissues. Monocytes that enter extravascular tissues differentiate into cells called macÂ�rophages, which, unlike neutrophils, survive in these sites for long periods. Blood monocytes and tissue macrophages are two stages of the same cell lineage, which often is called the mononuclear phagocyte system (Fig. 2–8). ) Resident macrophages are found in healthy connective tissue and all organs in the body. Macrophages serve several important roles in host defense—they produce cytokines that initiate and regulate inflammation, they ingest and destroy microbes, and they clear dead tissues and initiate the process of tissue repair (Fig.