By John Douglas M.Sc. Ph.D. D.I.C. M.I.Biol (auth.)

The contribution of bacteriophages to the improvement of contemporary biology can't be overvalued but, sixty years after their discovery, they're as distant and mysterious to many scientists as they're to so much laymen. This publication endeavours to therapy the location: an try out has been made to supply, in comfortably understandable shape, a nucleus of knowledge necessary to a person embarking at the learn of bacteriophages or utilizing them of their paintings for the 1st time. It exhibits the diversity of bacteriophage constitution and behavior; it illustrates the function of bacteriophage in molecular biology; it surveys the present state-of-the-art; it offers the scientific and commercial points. a few basic experimental tactics are given in adequate element for the newbie to aim them effectively. different, extra refined seasoned­ cedures are offered with a view to impart a sense of intimate fact with out superb the reader with technical complexity. i am hoping that younger readers will forgive me for assuming that they've a few wisdom of micro organism, nucleic acids, antibodies and isotopes. Likewise i'd ask mature staff to excuse the omission of adored specialities. To have integrated these kind of, helpful notwithstanding they're, may need placed this ebook past the re ach of the phage-novices for whom it truly is meant. particular references, store some of specific curiosity, were passed over. different books on bacteriophage v vi BACTERIOPHAGES supply them in abundance.

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C. In this novel design the power pack and vacuum system are contained in the console; by having the column below bench level mechanical stability is improved and a very compact instrument is possible. The filament is in the lower end of the column. The specimen holder is inserted at d. The phosphor is applied directly to the back of viewing window e, giving a very bright image. It can be viewed in moderate room lighting, unlike A which must be used in almost total darkness. D. The specimen holder for C takes four grids at f.

It is a lipoprotein molecule of high molecular weight. When phage T5 and its receptor are incubated in vitra, electron microscopy shows that the receptor molecules become attached to the tip of the tail. In phage T4 the tail fibres are wound tightly around the tail and cannot function in tryptophan-free media. Tryptophan allows the fibres to unwind. Many phages have a very definite requirement for divalent cations particularly calcium, which promotes adsorption and without which infection may fail to occur at all.

In the heads of certain highly defective mutant phages ('polyheads') a subunit structure can indeed be seen. 2 Other tailed phages The contractile tails of coliphages T2, T4 and T6 (the 'T-even' series) are virtually identical and there are many other phages of other bacteria whose tails are similar although they may vary in length and details of the collar, end-plate and fibres (if any). The contractile tail is a very efficient mechanism and those phages that have it tend to be adsorbed rapidly.

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