By Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev

This ebook explores key functions of phage biotechnology and studies fresh advances in phage reveal applied sciences. The functions lined have been chosen at the foundation in their importance and representativeness within the box.

The small measurement and large range of bacteriophages lead them to perfect applicants for various purposes throughout many industries. because the discovery of phages and the arrival of phage show platforms, substantial awareness has been all for the advance of novel healing and commercial purposes. fresh reports mix the genomic flexibility of phages with phage reveal platforms so that it will generate transformed phages for distinctive delivery.

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Extra resources for Bacteriophage Applications - Historical Perspective and Future Potential

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Molecular Therapy: The Journal of the American Society of Gene Therapy, 17(5), 767–777. Smith, G. , & Petrenko, V. A. (1997). Phage display. Chemical Reviews, 2665(96), 391–410. , & Verma, I. M. (2000). Gene therapy: Trials and tribulations. Nature Reviews Genetics, 1(2), 91–99. , & Makowski, L. (1992). Construction of a microphage variant of filamentous bacteriophage. Journal of Molecular Biology, 228(3), 720–724. 1016/0022-2836(92)90858-H Sperinde, J. , Choi, S. , & Szoka, F. C. (2001). Phage display selection of a peptide DNase II inhibitor that enhances gene delivery.

Overall, the capability to pass the blood brain barrier and penetrate heterogeneous neural tissue is highly desirable in a CNS-targeted therapeutic. Phage have been observed to exhibit this ability (Dabrowska et al. 2005; Frenkel and Solomon 2002) and may therefore be exploited for CNS drug and gene delivery. Drug addiction is an important health and social problem world-wide, a prevailing culprit of which is the highly addictive recreational drug cocaine. It has been previously shown that protein-based therapeutics designed to bind to cocaine can reduce the drug load and attenuate its psychoactive effects.

However, the use of such vectors poses important safety concerns, particularly with respect to the control of inherent virulence and immunogenicity (Clark et al. 2012; Seow and Wood 2009), which can and have previously resulted in mortality (Somia and Verma 2000). An additional challenge is the effective design of viral therapeutics to target the desired organ or tissue and to avoid prior immunity against viral vectors (Nayak and Herzog 2010). As such, there is a need for gene therapy systems that are benign and yet more precise, which has drawn attention to alternate approaches such as bacteriophage-mediated gene delivery.

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