By Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev
This ebook explores key functions of phage biotechnology and studies fresh advances in phage reveal applied sciences. The functions lined have been chosen at the foundation in their importance and representativeness within the box.
The small measurement and large range of bacteriophages lead them to perfect applicants for various purposes throughout many industries. because the discovery of phages and the arrival of phage show platforms, substantial awareness has been all for the advance of novel healing and commercial purposes. fresh reports mix the genomic flexibility of phages with phage reveal platforms so that it will generate transformed phages for distinctive delivery.
Read Online or Download Bacteriophage Applications - Historical Perspective and Future Potential PDF
Similar cell biology books
This publication has compatible intensity and insurance, nice for someone that feels that Lewin's GENES is simply too long. It has first-class reference lists for person who desires to understand extra. It has transparent diagrams and used to be written elegantly. but it isn't up-to-date often.
The seriously acclaimed laboratory average, tools in Enzymology , is likely one of the such a lot hugely revered guides within the box of biochemistry. considering that 1955, each one quantity has been eagerly awaited, often consulted, and praised through researchers and reviewers alike. The sequence includes a lot fabric nonetheless suitable at the present time - really a vital booklet for researchers in all fields of lifestyles sciences.
This quantity on Genetics, Genomics, and Informatics, will conceal new applied sciences in ahead and opposite Genetics, Transgenesis, The Zebrafish Genome and Mapping applied sciences, Informatics and Comparative Genomics, and Infrastructure. This quantity of equipment in mobile Biology will end up helpful either to pro zebrafish investigators in addition to to those that are newly adopting the zebrafish version as a part of their study armamentarium.
This certain quantity of The Enzymes is concentrated towards researchers in biochemistry, molecular and mobilephone biology, pharmacology, and melanoma. This thematic quantity discusses inhibitors of the Ras superfamily G-proteins. Key positive factors: * Contributions from best experts * Informs and updates on the entire most modern advancements within the box
Extra resources for Bacteriophage Applications - Historical Perspective and Future Potential
Molecular Therapy: The Journal of the American Society of Gene Therapy, 17(5), 767–777. Smith, G. , & Petrenko, V. A. (1997). Phage display. Chemical Reviews, 2665(96), 391–410. , & Verma, I. M. (2000). Gene therapy: Trials and tribulations. Nature Reviews Genetics, 1(2), 91–99. , & Makowski, L. (1992). Construction of a microphage variant of ﬁlamentous bacteriophage. Journal of Molecular Biology, 228(3), 720–724. 1016/0022-2836(92)90858-H Sperinde, J. , Choi, S. , & Szoka, F. C. (2001). Phage display selection of a peptide DNase II inhibitor that enhances gene delivery.
Overall, the capability to pass the blood brain barrier and penetrate heterogeneous neural tissue is highly desirable in a CNS-targeted therapeutic. Phage have been observed to exhibit this ability (Dabrowska et al. 2005; Frenkel and Solomon 2002) and may therefore be exploited for CNS drug and gene delivery. Drug addiction is an important health and social problem world-wide, a prevailing culprit of which is the highly addictive recreational drug cocaine. It has been previously shown that protein-based therapeutics designed to bind to cocaine can reduce the drug load and attenuate its psychoactive effects.
However, the use of such vectors poses important safety concerns, particularly with respect to the control of inherent virulence and immunogenicity (Clark et al. 2012; Seow and Wood 2009), which can and have previously resulted in mortality (Somia and Verma 2000). An additional challenge is the effective design of viral therapeutics to target the desired organ or tissue and to avoid prior immunity against viral vectors (Nayak and Herzog 2010). As such, there is a need for gene therapy systems that are benign and yet more precise, which has drawn attention to alternate approaches such as bacteriophage-mediated gene delivery.