By James B Peter; Yehuda Shoenfeld

This quantity is THE definitive, thoroughly up to date, reference paintings for ALL researchers and clinicians operating in autoimmunity.Up-to-Date: this can be a well timed serious overview of greater than a hundred autoantibodies by means of top specialists of their respective fields, and contains many fresh references.International specialists: The one hundred twenty Chapters were written by means of the pinnacle foreign cadre of authors who've supplied dependent, professional contributions.Comprehensive: a complete complete viewpoint at the approaches which result in, inhibit or another way have an effect on autoantibodies in humans.Useful to Researchers and Clinicians: Chapters regularly comprise tools of detection, pathogenic function, components in pathogenicity and genetics in addition to scientific software with sickness institutions and frequencies

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Hamlyn AN, Berg PA. Hemagglutinating antiactin antibodies in acute and chronic liver disease. Gut 1980;21:311-317. Hawkins BR, O'Connor KJ, Dawkins RL, Dawkins B, Rodger B. Autoantibodies in an Australian population. I. Prevalence and persistence. J Clin Lab Immunol 1979;2:211-215. Holborow EJ, Hemsted EH, Mead SV. Smooth muscle autoantibodies in infectious mononucleosis. Br Med J 1973;3:323325. Ironside PN, De Boer WG, Nairn RC. Smooth muscle antibody in lupoid hepatitis. Lancet 1966;i:1210. Johnson GD, Holborow EJ, Glynn LE.

Department of Clinical Neurology, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK H I S T O R I C A L NOTES Myasthenia gravis (MG) is a disorder in which autoantibodies to acetylcholine receptors (AChR) at the neuromuscular junction of skeletal muscle lead to AChR loss and muscle weakness (Table 1). MG was attributed to the presence of antibodies to muscle "endplate" protein as early as 1960 (Simpson, 1960), but the presence and role of antibodies to endplate acetylcholine receptors (anti-AChR) were not successfully demonstrated until the mid-seventies.

AFFINITY AND AVIDITY IN AUTOIMMUNE DISEASES Unlike conventional antibodies, the role of affinity and avidity in the function of autoantibodies is not clearly understood. How, if at all, autoantibody affinity and avidity are related to pathogenicity is controversial. The clinical relevance of avidity of autoantibodies is the subject of ongoing study. , 1993). During the past three decades, many investigators evaluated the relationship between anti-dsDNA avidity and lupus glomerulonephritis. , 1973).

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