By Dennis P. O'Malley (auth.)

The spleen is an organ which has different features together with immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the traditional and pathologic stipulations that afflict the spleen. This awesome selection of top of the range electronic photographs will materially reduction in carrying on with efforts to acknowledge, comprehend, and correctly interpret the gross and lightweight microscopic findings in spleens.

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129 Mycosis fungoides. This low magnification of spleen shows involvement by mycosis fungoides. Although typically an indolent T-cell lymphoma confined to skin, in some cases, diffuse systemic involvement may be present. The spleen shows massive expansion of the PALS regions by abnormal lymphocytes Fig. 127 Peripheral T-cell lymphoma. High magnification of peripheral T-cell lymphoma with red pulp involvement. Abnormal lymphocytes are within the splenic cords and some are in sinuses. They are small to intermediate in size with irregular nuclei Fig.

Splenic marginal zone cells will often colonize the periarteriolar lymphoid sheath (PALS) region Fig. 15 Splenic marginal zone lymphoma. In this example of splenic marginal zone lymphoma, there is evidence of plasmacytoid differentiation. Although rare, plasma cell differentiation can be seen in splenic marginal zone lymphoma. This phenomenon is more common than the presence of lymphoplasmacytic lymphoma in the spleen Fig. 14 Splenic marginal zone lymphoma with transformation to diffuse large B-cell lymphoma.

The dark material is “malarial pigment” Fig. 31 Chronic lymphocytic leukemia. In this example of CLL, there is an expanded white pulp nodule present. In the upper portion, there is evidence of a residual germinal center (arc-shaped area), surrounded by the lymphocytes of CLL. 3 3 Lymphoid Neoplasms Lymphoplasmacytic Lymphoma Fig. 34 Lymphoplasmacytic lymphoma. Low magnification of spleen with involvement by LPL. Spleens with LPL are rarely seen, likely due to rare significant involvement of spleen and little need for splenectomy as a diagnostic specimen Fig.

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