By Eliana Scemes, David C. Spray

Astrocytes play assorted roles in primary frightened approach (CNS) functionality and disorder, and the connections that the astrocyte makes with different cells of the mind are crucial for a number of vital neural initiatives. Bringing jointly contributions from overseas specialists on the most sensible in their box, Astrocytes: Wiring the mind emphasizes mobile connections and surveys the most up-tp-date findings on astrocyte Read more...

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1 Cx43 Mutations..................................................................... 6 Summary......................................................................................................... 49 Acknowledgments..................................................................................................... 50 References................................................................................................................. 1 THE MULTIDOMAINS OF ASTROCYTES Astrocytes are highly elaborated and ramified cells and likely the only neural cell that simultaneously establishes close morphological associations with most cellular types.

10 Harold K. ) AQP-4 and GFAP labeling of astrocytes in rat cortex. (A) GFAP immunolabeling of astrocytes. Individual astrocytes appear somewhat star shaped and are uniformly distributed, with little overlap with neighboring astrocytes. Astrocytic processes to blood vessels differ from other processes by being straight, unbranched, and of wider diameter (red arrowheads). The surfaces of large- to medium-size vessels were densely covered by GFAP+ astrocytic endfeet. Inset, an astrocyte with two vascular processes.

Each connexon is formed by six subunits, the connexins, which are tetraspan proteins, with cytoplasmic N- and C-termini, two extracellular loops (E1 and E2), and a cytoplasmic loop (CL). Biomarkers of Astrocyte Microdomains 29 intercellular interaction between connexons formed by a single connexin type (so-called homomeric, homotypic gap junctions) and also between many pairs of connexons formed by different connexin types (so-called heterotypic channels, with connexons formed by individual or multiple connexin types).

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