By M Sluyser

In apoptosis within the mammalian approach, cells have a finite lifestyles - they enhance, are used after which die. melanoma cells get away this programmed regimen yet, from an knowing of apoptosis, they are often programmed to die. This booklet addresses the

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R. (1990) Periodicity of DNA folding in higher order chromatin structures. EMBO J. 9, 1319–1327. BOULIKAS, T. (1993) Nature of DNA sequences at the attachment regions of genes to the nuclear matrix. J. Cell Biochem. 52, 14–22. , ROBERTSON, D. R. (1994) Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA. Exp. Cell. Res. 211, 231–237. R. A. (1973) Chromatin substructure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease.

USA 89, 7703–7707. , TORRIGLIA, A. F. (1994) DNA strand breakage during physiological apoptosis of the embryonic chick lens: free 3 OH end single strand breaks do not accumulate even in the presence of a cationindependent deoxyribonuclease. J. Cell Physiol. 158, 354–364. HAYAISHI, O. & UEDA, K. (1982) ADP-ribosylation reactions. Academic Press, New York. , UEDA, K. & HAYAISHI, O. (1980) Immunohistochemical demonstration of poly (adenosine diphosphate-ribose) in nuclei of various rat tissues. J.

1988) Cytotoxic T lymphocyte mediated cytolysis. Biochemistry 27, 2641–2646. J. D. (1989) Purified perform induces target cell lysis but not DNA fragmentation. J. Exp. Med. 170, 1451–1456. A. J. (1993) Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation. Immunol. Cell Biol. 71, 201–208. , HENGARTNER, H. G. (1991) A central role of perform in cytolysis? Annu. Rev. Immunol. 9, 129–157. , AEBERSOLD, R. H. (1992) A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

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