By Frank J. Dixon

The Scripps learn Institute, l. a. Jolla, CA. newest findings within the box of immunology. converted define structure.

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Extra resources for Advances in Immunology, Vol. 69

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1996). Thus, two functional TCRP chains are not toxic, and maturing thymocytes with two functional TCRP chains are not actively eliminated by some selection mechanism. It appears more likely that the failure to detect mature T cells with two distinct TCRP chains on the cell surface, even in pTa-deficient mice, is a result of the tight association between allelic exclusion and maturation: pairing of a functional TCRP chain with pTa and formation of a pre-TCR complex would result in rapid cell cycle induction, shut down of RAG gene expression, and progression to the next stage in differentiation.

1997). In fact, in TCRaP transgenic, pTa-’- mice the number of thymocytes was reduced by only about 50% compared to TCRaP transgenic, pTa+ mice, although the transgenic TCRa chain was expressed in only 9% of CD25’ pre-T cells, demonstrating that an ap TCR could mediate expansion of pre-T cells at least as efficient as a pre-TCR. Taken together, these data show that DP thymocytes can be generated by at least three distinct pathways, two of which are noticeable solely in mice in which the main route is experimentally blocked.

In contrast, none of these features were found in the population containing apparently nondividing, small cells (denoted E for "expected size"). Most important, the analysis of V(D)JP rearrangements by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) revealed that there was no enrichment of in-frame joints in population E. In contrast, cells of subset L had predominantly in-frame rearrangements. Interestingly, CD25+CD44-"" thymocytes from mutant mice unable to form a functional pre-TCR were reported to be almost exclusively of type E.

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