By Frederick W. Alt

Advances in Immunology, a usual and hugely revered book, provides present advancements in addition to finished studies in immunology. Articles tackle the big variety of issues that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored by way of the main scientists within the box, every one quantity presents up to date details and instructions for the future.

Key features:

* Contributions from major professionals * Informs and updates on all of the newest advancements within the box

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Extra resources for Advances in Immunology, Volume 121

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Proceedings of the National Academy of Sciences of the United States of America, 91, 158–162. O’Shea, J. , & Plenge, R. (2012). JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity, 36, 542–550. , & Leonard, W. J. (2002). Cytokine and cytokine receptor pleiotropy and redundancy. Journal of Biological Chemistry, 277, 29355–29358. , Kossiakoff, A. , & Sidhu, S. S. (2003). The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: Insights into the mechanisms responsible for improved affinity.

Novel anti-brain tumor cytotoxins specific for cancer cells. Nature Biotechnology, 16, 449–453. Delgoffe, G. , Murray, P. , & Vignali, D. A. (2011). Interpreting mixed signals: The cell’s cytokine conundrum. Current Opinion in Immunology, 23, 632–638. Depper, J. , Leonard, W. , Waldmann, T. , & Greene, W. C. (1985). Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proceedings of the National Academy of Sciences of the United States of America, 82, 4230–4234. de Vos, A. , & Kossiakoff, A.

Wiley, H. , & Lauffenburger, D. A. (1996). Engineering epidermal growth factor for enhanced mitogenic potency. Nature Biotechnology, 14, 1696–1699. , Wilson, I. , & Michnick, S. W. (1999). Erythropoietin receptor activation by a ligand-induced conformation change. Science, 283, 990–993. , Boulanger, M. , & Garcia, K. C. (2005). The structure of interleukin-2 complexed with its alpha receptor. Science, 308, 1477–1480. Ring, A. , Lin, J. , Bowman, G. , et al. (2012). Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

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