By Deepak L. Bhatt, Anthony A Bavry

Acute coronary syndromes (ACS) is an umbrella time period used to explain a sequence of signs indicative of myocardial ischemia, comprising volatile angina, non-ST phase elevation myocardial infarction, and ST section elevation myocardial infarction.

Managing Acute Coronary Syndromes in scientific perform is a vital source for the clinician within the administration of ACS. as well as offering a complete assessment of the epidemiology and medical presentation of ACS, it additionally courses the reader via danger evaluation, chance stratification, prognosis, and remedy of ACS. The e-book concludes with a dialogue on rising applied sciences within the remedy of ACS. The guide layout and considerable use of illustrations make this pocketbook a superb source for common Practitioners, Emergency drugs Physicians, Nurses, Nurse Practitioners, Pharmacists, surgeon Trainees, clinical scholars, Nursing scholars, and Paramedics who desire to continue updated with fresh advances within the knowing and remedy of ACS.

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Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 1996; 335:1342– 1349. 3. Antman EM, Cohen M, Bernink PJ, et al. The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA 2000; 284:835–842. 4. Cannon CP, Weintraub WS, Demopoulos LA, et al. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.

Platelet glycoprotein IIb/IIIa inhibitors: recognition of a twoedged sword? Circulation 2002; 106:379–385. 24. Bhatt DL, Topol EJ. Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. JAMA 2000; 284:1549–1558. 25. Boersma E, Harrington RA, Moliterno DJ, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomized clinical trials. Lancet 2002; 359:189–198. 26. Roffi M, Chew DP, Mukherjee D, et al. Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes.

When eptifibatide and tirofiban are used, they should be continued for 18–24 hours after intervention, although if these agents are initiated upstream, eptifibatide may be preferred as it has better data for use in percutaneous coronary intervention than tirofiban [4,5]. Glycoprotein IIb/IIIa inhibitors increase major bleeding, which is a potent predictor of short-term mortality [34]. 6 The impact of major bleeding on mortality from the ACUITY trial ACUITY, Acute Catheterization and Urgent Intervention Triage Strategy.

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